Mai Tokiha is an ordinary high-school girl who has recently transferred to the Fuka Academy with her younger brother, Takumi. However, a routine boat ride and a chance encounter with a mysterious young girl changes everything. Mai discovers that she and some of her classmates possess the powers of HiME and must battle against mysterious creatures called Orphans and an ominous organization called the Searrs Foundation. Along the way she must face her own demons and understand what it means to love.