When Ryunosuke's pet cat dies in an accident, his inventor father "resurrects" the cat by placing its brain in an android body made in the form of a young girl. The Android, Nuku nuku, has the dual purposes of being a companion/sister for Ryunosuke as well as being a bodyguard for his father. Nuku nuku's extreme strength and feline agility are regularly needed to protect Ryunosuke and his  father  from Ryunusuke's mother who seeks to kidnap them both following her divorce from his father. Her motives towards Ryunusuke are simple motherly love, however her genius-inventor-ex-husband she wants to put to work designing weapons of mass destruction for her weapons company.

Cast: All Purpose Cultural Cat Girl Nuku Nuku

Allison Keith as Nuku Nuku

Kira Vincent-Davis as Ryunosuke

Andrew Klimko as Kyusaku

Kaytha Coker as Arisa

Kelly Manison as Akiko

Tiffany Grant as Kyouko

Brett Weaver as Delinquent on Roof, Horny Teen in Glasses, Shinichi

Chad Townsend as Guy in Classroom

Cheryl Pierce as Female Monitor, Mother, Reporter

Chris Hawley as Guy in Classroom

Chris Patton as Buck-Tooth Horny Teen, Guy in Classroom, Shopkeeper, Traffic Reporter

Cynthia Martinez as Eimi

David Williams as Guy Outside School, Male Bather

Jason Lee as Delinquent on Roof, Guy in Classroom, Newscaster, Scientific Rep, Worker

Jessica Boone as Yoshimi

Ken Wiatrek as Ice Cream Vendor, Military Rep

Kim-Ly Nguyen as Mai Yazawa

Phil Ross as Grandfather

Randy Sparks as Fat Horny Teen, Male Monitor, Worker

Shelley Calene-Black as Angry Woman, Bunny Girl, Ryu's Teacher, Young Girl

Stephanie McFall as Cartoon Voice-Over

Stephanie Williams as Ryu's Friend

Ty Mayberry as Government Rep, The Other Horny Teen

Vic Mignogna as Guy Outside School, Manager, Soldier

Alex Dickinson

Carl Wormley

Christopher Williams

Dorothea Exis

Fumiko Chino

Jessica Williams

Matt Williams

Michael Hale

Mike Yantosca

Oye Gowboo

Shelly Thomas

Stan Thomas

Cast: All Purpose Cultural Cat Girl Nuku Nuku DASH!

Kira Vincent-Davis as Ryunosuke Natsume

Allison Keith as Nuku Nuku, Rei Rei - R204 (Ep. 12)

Andrew Klimko as Kyusaku Natsume

Chris Patton as Ozaki

Cynthia Martinez as Yuko

Eric Opella as Branch President's Aide, Computer, Tsubouchi

George Manley as Branch President/Vice Chief (eps 3-10), Keed Company Employee (ep 5), Manager (ep 2,4, 5)

H.K. Kahng as Shimazaki

Hilary Haag as Flower Girl

Jason Douglas as Ooizumi, Prof. Iguchi, Section Chief

Jason Konopisos as Assistant Manager

Jaz McKay as Executive C

Jennifer Todoroff as Noriko Ishiyama

John Tyson as Commander

Justin Jung as Warehouse Employee

Kaytha Coker as Ariso Sono

Kelly Manison as Akiko Natsume

Kim-Ly Nguyen as Mai Yawaza

Luci Christian as Momoko Ishiyami, Original Atsuko, Secretary

Marty Fleck as Executive A, President's Aide

Matt Kelley as Older Ryunosuke

Miguel Gandara as Flashy Porsche Man, Officer Mechanic

Mike Kleinhenz as Executive B

Monica Rial as Chouko Izumishikibu

Sandra Krasa as Adjutant

Sara Gaston as Shuko Yamamoto

Ted Pfister as Executive A

Tiffany Grant as Kyoko Ariyoshi

Tonya Metzger as Girl

Vic Mignogna as Young President

Ayanna Grundy

Bubba Callahan

Eric Opella

H.K. Kahng

Jason Douglas

Jason Konopisos

John Tyson

Kyle Jones

Marty Fleck

Matt Kelley

Sami Mikasa

Tonya Metzger