Azumanga Daioh is about high school life through the eyes of six girls with unusual personalities: Chiyo (the 10-year-old genius), Osaka (the resident airhead), Sakaki (the shy one prone to cat bites), Tomo (the loose cannon), Yomi (the short-tempered one) and Kagura (the resident jock).
It’s the girls’ first day of high school, which introduces a new world that they have to get used to. Although, that may be harder than it seems. They have to deal with their crazy English teacher Yukari, new classmates, a new environment, and even more craziness than ever before!
It’s Osaka time! Osaka tries hard at school - during classes, during gym, and even during lunch. But, is that good enough?!
Yukari and Minamo (or "Nyamo" as she's often called by Yukari) are two close friends who are both teaching at the same school. The girls learn more about them and their past friendship. But, the biggest question is, why does Yukari call Minamo Nyamo?
Kimura, a teacher at the high school, has a weird taste in girls. He seems to have a thing for high school girls! Is he a pervert or is he just misunderstood?
It’s finally summer vacation! Chiyo invites the girls over to her summerhouse for fun at the beach. Yukari and Nyamo both tag along as well.
It’s Sports Day and the school is holding an athletics festival. Will Yukari’s class and Sakaki win, or will Nyamo’s and Kagura?
The Cultural Festival is right around the corner and Yukari doesn’t want to loose to Nyamo. What idea will Yukari’s Class 3 comes up with for the festival?
It’s the New Year! It’s said that the first dream you have of the New Year will determine what kind of year you have. What will Osaka, Tomo, Sakaki, and Kaorin all dream about?
It’s Chiyo’s eleventh birthday and Yomi, Tomo, Osaka, and Sakaki are all invited over. What presents will the girls get for her?
Osaka and Kaorin worry that they won't be in the same class as their friends this year, but Yukari has a cunning plan...
Now that Kagura and Sakaki are in the same class, they are no longer rivals. But, can they be friends? Kagura obviously has no love for cute things, unlike Sakaki who loves cute cats.
Chiyo is only eleven years old, yet she is already in high school. She misses the days when she could just play with children her own age and be what she is, a kid. Meanwhile, Sakaki comes over to play with Tadakichi, Chiyo’s dog.
It’s exam time for Chiyo and her friends. How will each of them do? Will they manage to hold their nerve? Who will come out on the top? Who will come out on the bottom?
It’s summer break again, and Chiyo invites her friends to her summerhouse! In addition, there’ s a summer festival occurring. It’s time for the girls to take a break from school and just have fun!
As the girls prepare for the annual school sporting competition, the girls discover that their weird, perverted teacher Kimura has a wife and a daughter! More crazy events unfold from a Basket Scramble to a 10k marathon in which everyone has to participate.
It’s time for the cultural festival once again. This time, the girls decide on a cute café!
It’s December, and Christmas is around the corner. The girls talk about pandas, Santa, and reindeer, while Yukari deals with a Xmas catalog and teaching P.E. The girls also go shopping, sing karaoke, and even see the first snow of the season!!
Winter Break has ended and the girls return to school for the New Year. Everyone is jealous that Yomi went to Hokkaido for break, so they all plan a trip to the theme park Magical Land. Unfortunately, Yomi gets sick!
It’s springtime and the Cherry Blossoms are blooming. The girls wonder if they have too much free time on their hands. Meanwhile, Nyamo and Yukari wonder if they are too childish.
The girls are now in their third year, entering their last year in High School. Things are changing and the girls start to think about college and their future jobs. Yukari`s Birthday: Yukari is jealous when Nyamo gets a present. Spread your wings Chiyo - Child President: college/career aspirations. Please Let Me Be Strong: Kaorin tries to survive creepy Kimura`s attentions.
The girls take a class trip to Okinawa. There, they have fun taking in the sites and eating the wonderful Okinawan food.
It’s the girls’ last summer vacation together. Tomo wants to go to Chiyo’s summer house and continue their tradition, but the girls have to study. So, they attempt to do both at the house.
It is the girls’ final sports fest in high school and they are all fired up and looking forward to it. Each girl is pumped for an event, but can they succeed in it. And, will Chiyo slow the class down in their final relay race?
Sakaki is reunited with the Iriomote Mountain Kitten that she met on the school trip to Okinawa. His mother was killed in a traffic accident the day after their trip. Soon, the “Yamamaya” whom Sakaki soon named Maya, finds Sakaki. Will Sakaki be able to keep Maya.
The girls choose their future careers and prep for their exams. Will they all pass?
It’s the last day of high school for the girls. After this graduation day, they are no longer high school students. They all find it hard to come to terms with the fact that their school days are over. But, they realize that their time together was not for nothing and is not over.